glp1ledger

Evidence-first, hype-free

Making sense of GLP-1 medicines, one clear answer at a time.

Semaglutide, tirzepatide, and what’s next — compared side by side, costs explained, evidence read calmly. No hype, no fear.

Our editorial standardsStart here

At a glance

SemaglutideGLP-1 · weekly
TirzepatideGIP + GLP-1 · weekly
Retatrutidein trials · not approved

Reviewed for accuracy · updated as evidence lands

Illustration: A wide sunlit kitchen table with a glass of water, a bowl of fruit and reading glasses on a folded newspaper.

First answers

COMPARISON

Tirzepatide vs semaglutide: the one trial that compared them directly

COSTS

How much GLP-1 medicines cost in 2026: every price, dated

COSTS

GLP-1 pills in 2026: what the two approved tablets cost, and what they do

COSTS

What Zepbound costs, and the 45-day rule behind its cheapest price

COSTS

What Mounjaro costs, and the list price hidden in its own savings card

COSTS

What Wegovy costs: every dose, every route, dated

COSTS

What Ozempic costs, and why it costs more than Wegovy

COMPARISON

Orforglipron vs tirzepatide: a daily pill against a weekly injection

COMPARISON

Survodutide vs tirzepatide: reading a brand-new phase 3 against an approved drug

COMPARISON

Retatrutide vs tirzepatide: what the trials show, and what is not known yet

COMPARISON

Compounded tirzepatide vs Zepbound: what changed when the shortage ended

REGULATION

Compounded semaglutide in 2026: what replaced it, and the generic already approved

IN DEVELOPMENT

Retatrutide: approval status, trial doses, results and what is sold under its name

SIDE EFFECTS

GLP-1 medicines and alcohol: what the trials found, and what the labels say

BRAIN AND COGNITION

What the GLP-1 brain research actually found

PATCHES AND SUPPLEMENTS

GLP-1 patches: what they contain, and the 4,114-dalton problem

PATCHES AND SUPPLEMENTS

GLP-1 supplements: the trials that exist, including the one that failed

SIDE EFFECTS

GLP-1 overdose: seven labels, and not one of them names a number

COSTS

The Medicare GLP-1 Bridge: who qualifies, and when $50 is the worse price

EXPLAINER

Oral GLP-1s: four products, two chemistries, one label that says they are not interchangeable

The ledger, weekly

One calm email a week: what changed, what it means, no noise.

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